期刊
CURRENT BIOLOGY
卷 15, 期 14, 页码 R563-R574出版社
CELL PRESS
DOI: 10.1016/j.cub.2005.07.010
关键词
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资金
- NCI NIH HHS [CA69577, CA63071, CA42978] Funding Source: Medline
- NIGMS NIH HHS [GM65533] Funding Source: Medline
Ras proteins function as signaling hubs that are activated by convergent signaling pathways initiated by extracellular stimuli. Activated Ras in turn regulates a diversity of downstream cytoplasmic signaling cascades. Ras proteins are founding members of a large superfamily of small GTPases that have significant sequence and biochemical similarities. Recent observations have established a complex signaling interplay between Ras and other members of the family. A key biochemical mechanism facilitating this crosstalk involves guanine nucleotide exchange factors (GEFs), which serve as regulators and effectors, as well as signaling integrators, of Ras signaling.
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