期刊
NATURE
卷 436, 期 7050, 页码 518-524出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nature03799
关键词
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资金
- NCI NIH HHS [P01 CA094060] Funding Source: Medline
By means of in vivo selection, transcriptomic analysis, functional verification and clinical validation, here we identify a set of genes that marks and mediates breast cancer metastasis to the lungs. Some of these genes serve dual functions, providing growth advantages both in the primary tumour and in the lung microenvironment. Others contribute to aggressive growth selectively in the lung. Many encode extracellular proteins and are of previously unknown relevance to cancer metastasis.
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