期刊
JOURNAL OF MEDICINAL CHEMISTRY
卷 48, 期 15, 页码 5038-5042出版社
AMER CHEMICAL SOC
DOI: 10.1021/JM040905D
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The proteasome is a multicatalytic proteinase complex which plays a central role in intracellular protein degradation. We report here the synthesis and biological activities of a new class of specific proteasome inhibitors selective for trypsin-like activity. These tripeptide-based compounds bearing a C-terminal vinyl ester are nontoxic, and do not affect cell proliferation, but are able to modulate the generation and presentation of immunogenic peptides presented by MHC class I molecules.
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