期刊
APPLIED SURFACE SCIENCE
卷 248, 期 1-4, 页码 344-348出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.apsusc.2005.03.111
关键词
pulsed laser deposition; biomimetic; coatings; calcium phosphate; octacalcium phosphate; carbonated manganese-doped hydroxyapatite
We review the progress made by us using pulsed laser deposition (PLD) of two bioactive calcium phosphates: octacalcium phosphate (OCP) and Mn doped carbonated hydroxyapatite (Mn-CHA). Coatings of these materials well suited for biomimetic medical prostheses and pivots were synthesized on titanium substrates with a pulsed KrF* UV laser source. The best deposition conditions for Mn-CHA thin films were 13 Pa O-2, 400 degrees C with post heat treatment of 6 h in air enriched with water vapours. The coatings are stoichiometric and crystalline. For OCP, deposition at 150 degrees C in 50 Pa water vapor atmosphere, post treated by 6 h annealing in hot flux of water vapours, resulted in stoichiometric, but poorly-crystallized films. Degradation tests show different behavior for the OCP and Mn-CHA coatings. In vitro cell growth shows excellent adherence and biocompatibility of osteoblasts and fibroblasts in both OCP and Mn-CHA coatings. Human osteoblasts display normal proliferation and viability, and good differentiation behaviour. (c) 2005 Elsevier B.V. All rights reserved.
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