Synthesis, characterization and biological studies of ferrocenyl complexes containing thiophene moiety

A new ferrocenyl ligand was prepared from the condensation of 1,1'-diacetylferrocene dihydrazone with 2-thiophenealdehyde. The ligand, 1,1'-bis[(2-thienylmethylidene)hydrazono-1-ethyl]ferrocene, forms 1:1 complexes with cobalt(II), nickel(II), copper(II) and zinc(II) in good yield. Characterization of the ligand and complexes was carried out using IR,H-1 NMR, electronic absorption and elemental analysis. Biological activity of the ligand and its complexes was assessed against Bacillus subtilis (+ve), Staphylococcus aureus (+ve), Candida albicans (yeast), Esherichia coli (-ve), Salmonella typhi (-ve), Aspergillus niger (fungi), and Fusarium solani (fungi). The biological results indicated that the complexes prepared are more active than the ligand. Copyright (c) 2005 John Wiley & Sons, Ltd.