A new fungicide produced by a Streptomyces sp GAAS7310

Directed bioassay guided fraction led to a new macrodiolide antimycin A(17) (1), isolated from a Streptomyces sp. GAAS7310, which showed significant antimicrobial activity against eleven fungal species, including Curvularia lunata (Wakker) Boed, Rhizopus nigrtcans Ehrb and Colletotrichum nigrum EL. et Halst. The structure was unambiguously established by interpretation of ID and 2D NMR data and comparison with the known antimycin A(1a).