期刊
NATURE NEUROSCIENCE
卷 8, 期 8, 页码 1059-1068出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1499
关键词
-
资金
- NICHD NIH HHS [HD24064] Funding Source: Medline
- NIMH NIH HHS [K05 MH065670, R01 MH49428] Funding Source: Medline
- NINDS NIH HHS [NS 29709, R01 NS40272] Funding Source: Medline
Dlx homeodomain transcription factors are essential during embryonic development for the production of forebrain GABAergic interneurons. Here we show that Dlx1 is also required for regulating the functional longevity of cortical and hippocampal interneurons in the adult brain. We demonstrate preferential Dlx1 expression in a subset of cortical and hippocampal interneurons which, in postnatal Dlx1 mutants, show a time-dependent reduction in number. This reduction preferentially affects calretinin(+) ( bipolar cells) and somatostatin(+) subtypes ( for example, bitufted cells), whereas parvalbumin(+) subpopulations ( basket cells and chandelier cells) seem to be unaffected. Cell transplantation analysis demonstrates that interneuron loss reflects cell-autonomous functions of Dlx1. The decrease in the number of interneurons was associated with a reduction of GABA-mediated inhibitory postsynaptic current in neocortex and hippocampus in vitro and cortical dysrhythmia in vivo. Dlx1 mutant mice show generalized electrographic seizures and histological evidence of seizure-induced reorganization, linking the Dlx1 mutation to delayed-onset epilepsy associated with interneuron loss.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据