4.6 Article

SdrA, a New DeoR Family Regulator Involved in Streptomyces avermitilis Morphological Development and Antibiotic Production

期刊

APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 79, 期 24, 页码 7916-7921

出版社

AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.02843-13

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资金

  1. Japan Society for the Promotion of Science (JSPS)
  2. Joint Program in the Field of Biotechnology from JSPS
  3. National Research Council of Thailand
  4. National Science and Technology Development Agency of Thailand
  5. JSPS [24310157, 24651243, 24780071]
  6. Promotion Program for Young Scientists from MEXT
  7. COE for Innovation of Marine Science and Technology from MEXT
  8. Grants-in-Aid for Scientific Research [24651243, 24780071] Funding Source: KAKEN

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The SAV3339 (SdrA) protein of Streptomyces avermitilis, a member of the DeoR family of regulators, was assessed to determine its in vivo function by gene knockdown through the use of cis-encoded noncoding RNA and knockout of the sdrA gene. These analyses revealed that SdrA represents another class of Streptomyces regulator that controls morphological development and antibiotic production.

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