期刊
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
卷 382, 期 8, 页码 1771-1782出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00216-005-3335-9
关键词
fluorescence spectroscopy; single-molecule detection; microfluidics; cytometry; lab-on-a-chip
Both single-molecule detection (SMD) methods and miniaturization technologies have developed very rapidly over the last ten years. By merging these two techniques, it may be possible to achieve the optimal requirements for the analysis and manipulation of samples on a single molecule scale. While miniaturized structures and channels provide the interface required to handle small particles and molecules, SMD permits the discovery, localization, counting and identification of compounds. Widespread applications, across various bioscience/analytical science fields, such as DNA-analysis, cytometry and drug screening, are envisaged. In this review, the unique benefits of single fluorescent molecule detection in microfluidic channels are presented. Recent and possible future applications are discussed.
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