期刊
CHEMICAL & PHARMACEUTICAL BULLETIN
卷 53, 期 8, 页码 952-957出版社
PHARMACEUTICAL SOC JAPAN
DOI: 10.1248/cpb.53.952
关键词
desymmetrization; cyclohexa-1,4-diene; intramolecular haloetherification; (+)-hydrobenzoin; ene acetal
A novel asymmetric synthesis of the cyclohexane derivative functionalized by some substituents has been developed from the diene acetals (1), prepared from the corresponding diene aldehyde and (+)-hydrobenzoin. The treatment of 1 with NBS in the presence of MeOCH2CH2OH predominantly afforded 2 in a stereoselective manner. Subsequent alkylation of the methoxyethoxy group produced the optically active cyclohexene compounds (3) in good yields. The stereoselective chemical modification of the remaining olefin in 3 was made by OsO4-oxidation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据