期刊
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 80, 期 3, 页码 928-934出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.03133-13
关键词
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资金
- Institut National de la Recherche Agronomique
- Institut Pasteur de Lille
- EU MetaHit (Metagenomics of the Human Intestinal Tract) project [HEALTH-F4-2007-201052]
Streptococcus salivarius is one of the first colonizers of the human oral cavity and gut after birth and therefore may contribute to the establishment of immune homeostasis and regulation of host inflammatory responses. The anti-inflammatory potential of S. salivarius was first evaluated in vitro on human intestinal epithelial cells and human peripheral blood mononuclear cells. We show that live S. salivarius strains inhibited in vitro the activation of the NF-kappa B pathway on intestinal epithelial cells. We also demonstrate that the live S. salivarius JIM8772 strain significantly inhibited inflammation in severe and moderate colitis mouse models. These in vitro and in vivo anti-inflammatory properties were not found with heat-killed S. salivarius, suggesting a protective response exclusively with metabolically active bacteria.
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