期刊
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 78, 期 15, 页码 5424-5431出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.00046-12
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资金
- National Institute of Allergy and Infectious Diseases [R01AI073971, R01AI097116]
In this study, we tested the hypothesis that the SdiA proteins of Escherichia coli and Salmonella enterica serovar Typhimurium respond to indole. While indole was found to have effects on gene expression and biofilm formation, these effects were not sdiA dependent. However, high concentrations of indole did inhibit N-acyl-L-homoserine lactone (AHL) sensing by SdiA. We conclude that SdiA does not respond to indole but indole can inhibit SdiA activity in E. coli and Salmonella.
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