期刊
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 79, 期 5, 页码 1508-1515出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.03417-12
关键词
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资金
- National Science Fund for Distinguished Young Scholars [31125021]
- National High Technology Research and Development Program of China (863 Program) [2011AA100901, 2011AA100902]
- National Basic Research Program of China (973 Program) [2012CB720802]
- National Natural Science Foundation of China [31200691]
- Key Program of the National Natural Science Foundation of China [20836003]
- National Science and Technology Pillar Program [2010C0070311]
- 111 Project [B07029]
- Fundamental Research Funds for the Central Universities [JUSRP111A31]
This study evaluated the protective effects of Lactobacillus plantarum CCFM8610, a selected probiotic with good cadmium binding capacity, against acute cadmium toxicity in mice. Ninety mice were divided into prevention and therapy groups. In the prevention groups, CCFM8610 was administered at 10(9) CFU once daily for 7 days, followed by a single oral dose of cadmium chloride at 1.8 mg cadmium for each mouse. In the therapy groups, the same dose of CCFM8610 was administered for 2 days after an identical single dose of cadmium exposure. Mice that received neither cadmium nor culture or that received cadmium alone served as negative and positive controls, respectively. The effects of both living and dead CCFM8610 on cadmium ion concentrations in feces, liver, and kidney were determined. Moreover, the alterations in reduced glutathione (GSH), malondialdehyde (MDA), superoxide dismutase (SOD), catalase (CAT), and histopathology in the liver and kidney were investigated. The results showed that compared to the mice that received cadmium only, CCFM8610 treatment can effectively decrease intestinal cadmium absorption, reduce tissue cadmium accumulation, alleviate renal and hepatic oxidative stress, and ameliorate hepatic histopathological changes. Living CCFM8610 administered after cadmium exposure offered the most significant protection. Our results suggested that CCFM8610 is more effective against acute cadmium toxicity than a simple antioxidant treatment due to its special physiological functions and that it can be considered a new dietary therapeutic strategy against acute cadmium toxicity.
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