期刊
NATURE REVIEWS IMMUNOLOGY
卷 5, 期 8, 页码 629-640出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nri1664
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- Medical Research Council [G9219675] Funding Source: Medline
- MRC [G9219675] Funding Source: UKRI
- Medical Research Council [G9219675] Funding Source: researchfish
- The Sir Jules Thorn Charitable Trust [02JTA] Funding Source: researchfish
Interleukin-1 is a pro-inflammatory cytokine that has numerous biological effects, including activation of many inflammatory processes ( through activation of T cells, for example), induction of expression of acute-phase proteins, an important function in neuroimmune responses and direct effects on the brain itself. There is now extensive evidence to support the direct involvement of interleukin-1 in the neuronal injury that occurs in both acute and chronic neurodegenerative disorders. This article discusses the key evidence of a role for interleukin-1 in acute neurodegeneration - for example, stroke and brain trauma - and provides a rationale for targeting the interleukin-1 system as a therapeutic strategy.
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