期刊
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 79, 期 5, 页码 1751-1754出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.03626-12
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资金
- Institute of Molecular Infection Biology, University of Wurzburg
- Research Center for Infectious Diseases
- University of Wurzburg
- Free State of Bavaria
- Microbiology Institute of the University Hospital of Erlangen
- Forderprogramm fur Forschung und Lehre of the Ludwig-Maximilians-Universitat
- Munchner Medizinische Wochenschrift
- Deutsche Forschungsgemeinschaft [KR2294/1-3, WA3016/1-1]
- European Science Foundation
- FUMINOMICS Research Networking Programme [06-RNP-132]
Conditional gene expression is key for functional studies in any given microorganism. To allow tight regulation in the pathogenic mold Aspergillus fumigatus, improved versions of the doxycycline-dependent Tet-On system were generated by replacing functional elements of the precursor module, thereby circumventing the former problem of leakiness due to intramolecular recombination.
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