期刊
BEHAVIORAL NEUROSCIENCE
卷 119, 期 4, 页码 884-891出版社
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.119.4.884
关键词
amyloid; recognition; familiarity; object; location; memory
资金
- MRC [G9724886] Funding Source: UKRI
- Medical Research Council [G9724886] Funding Source: researchfish
- Medical Research Council [G9724886] Funding Source: Medline
- Wellcome Trust Funding Source: Medline
The present study examined the effects of a human APPswe mutation on object recognition memory in adult Tg2576 mice. The results showed that 14-month old Tg2576 mice were able to detect object novelty as well as control mice, even with delays of up to 24 hr. In addition, transgenic mice showed a normal recency effect and explored the most recently encountered object significantly less than an object encountered earlier in a trial. However, adult Tg2576 mice showed impairments in detecting a change in the relative positions of an array of familiar objects. The results suggest that the formation of representations involving a combination of object identity and spatial information are particularly sensitive to amyloid pathology in adult APPswe mutant mice.
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