期刊
CANCER GENE THERAPY
卷 12, 期 8, 页码 665-672出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/sj.cgt.7700828
关键词
protein tyrosine phosphatase; PTPRO; DNA methylation; gene reactivation; DNA hypomethylating agents; HDAC inhibitors
类别
资金
- NCI NIH HHS [CA 86978, R01 CA081024, CA 81024, R01 CA081024-01A2, R01 CA086978, R01 CA086978-01A2] Funding Source: Medline
- NIEHS NIH HHS [ES 10874, R01 ES010874] Funding Source: Medline
Promoter methylation-mediated silencing is a hallmark of many established tumor suppressor genes. This review focuses on the methylation and suppression of a receptor-type tyrosine phosphatase gene, PTPRO, in a variety of solid and liquid tumors. In addition, PTPRO exhibits many other characteristics of a bona fide tumor suppressor. Reactivation of genes silenced by methylation using inhibitors of DNA methyltransferases and histone deacetylases, and the potential application of PTPRO as a molecular target for cancer therapy have been discussed.
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