期刊
MAGNETIC RESONANCE IN MEDICINE
卷 54, 期 2, 页码 373-385出版社
WILEY
DOI: 10.1002/mrm.20561
关键词
brain tissue labeling; T-1; weighting; optimization (simulated annealing); functional mapping; double inversion recovery
A new magnetization preparation and image acquisition scheme was developed to obtain high-resolution brain images with optimal tissue contrast. The pulse sequence was derived from an optimization process using simulated annealing, without prior assumptions with regard to the number of radiofrequency (RF) pulses and flip angles. The resulting scheme combined two inversion pulses with the acquisition of three images with varying contrast. The combination of the three images allowed separation of gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF) based on T-1 contrast. It also enabled the correction of small errors in the initial T, estimates in post-processing. The use of three-dimensional (313) sensitivity-encoded (SENSE) echo-planar imaging (EPI) for image acquisition made it possible to achieve a 1.15(3) mm(3) isotropic resolution within a scan time of 10 min 21 s. The cortical GM signal-to-noise ratio (SNR) in the calculated GIVI-only image varied between 30 and 100. The novel technique was evaluated in combination with blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRl) on human subjects, and provided for excellent coregistration of anatomical and functional data.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据