期刊
EUROPEAN JOURNAL OF VASCULAR AND ENDOVASCULAR SURGERY
卷 30, 期 2, 页码 137-142出版社
W B SAUNDERS CO LTD
DOI: 10.1016/j.ejvs.2005.02.047
关键词
genetics; cardiovascular disease; 5,10-methylenetetrahydrofolate reductase (MTHFR); abdominal aortic aneurysm; peripheral vascular disease; coronary artery disease.
Objectives. To test whether the T variant of the C677T polymorphism in the gene for 5,10-methylenetetraltydrofolate reductase (MTHFR) would associate with three distinct forms of vascular disease, abdominal aortic aneurysm (AAA), coronary artery disease (CAD) and peripheral vascular disease (PVD). Background. Increases in homocysteine induce elastolytic activity in the arterial wall, a condition which may favour vascular pathogenesis including aneurysm formation. Homozygosity of the common T variant of the C677T polymorphism in the gene for MTHFR has been shown to associate with increased levels of homocysteine, Thus, this functional polymorphism may lead to an increased propensity to develop cardiovascular disease and, in particular, AAA. Methods. An association study was conducted across 1207 subjects; 428 patients with AAA, 271 CAD patients, 226 PVD patients and 282 controls being genotyped for the C667T variants of MTHFR. Results. There were no significant differences in the frequency of the MTHFR C677T variant between any of the groups examined. AAA patients who were homozygotes for the 677T allele did, however, appear to have significantly larger aneurysms than C allele carriers. Conclusion. This study provides no evidence that the T variant of MTHFR is associated with susceptibility to AAA, CAD or PVD. It may, however, be a contributory factor in AAA severity as indicated by aneurysm size.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据