期刊
HEARING RESEARCH
卷 206, 期 1-2, 页码 200-226出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.heares.2005.02.013
关键词
tinnitus; plasticity; dorsal cochlear nucleus; tinnitus mechanisms; neural correlates of tinnitus; tinnitus generation; tinnitus modulation; deafferentation; mechanisms
资金
- NIDCD NIH HHS [R01 DC03258] Funding Source: Medline
Tinnitus displays many features suggestive of plastic changes in the nervous system. These can be categorized based oil the types of manipulations that induce them. We have categorized the various forms of plasticity that characterize tinnitus and searched for their neural underpinnings in the dorsal cochlear nucleus (DCN). This structure has been implicated as a possible site for the generation of tinnitus-producing signals owing to its tendency to become hyperactive following exposure to tinnitus inducing agents such as intense sound and cisplatin. In this paper, we review the many forms of plasticity that have been uncovered in anatomical, physiological and neurochemical Studies of the DCN. Some of these plastic changes have been observed as consequences of peripheral injury or as fluctuations in the behavior and chemical activities of DCN neurons, while others can be induced by stimulation of auditory or even non-auditory structures. We show that many parallels can be drawn between the various forms of plasticity displayed by tinnitus and the various forms of neural plasticity which have been defined in the DCN. These parallels lend further support to the hypothesis that the DCN is an important site for the generation and modulation of tinnitus-producing signals. (c) 2005 Elsevier B.V. All rights reserved.
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