期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 16, 期 4-5, 页码 474-486出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2005.03.010
关键词
hypoxia; reactive oxygen species; HIF; oxygen sensing; NADPH oxidase
Reactive oxygen species (ROS) have long been considered as cytotoxic. However, recent evidence indicates a prominent role of ROS as signaling molecules in the response to hormones, growth and coagulation factors, cytokines and other factors as well as to changes in oxygen tension. The hypoxia-inducible transcription factors (HIFs) are key players in the cellular response to changes in oxygen tension. Recently, HIFs have also been shown to respond to the above-mentioned non-hypoxic stimuli. In this article, the role of ROS in the regulation of HIF-1 under hypoxic and non-hypoxic conditions is summarized. (c) 2005 Elsevier Ltd. All rights reserved.
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