期刊
JOURNAL OF NEUROVIROLOGY
卷 11, 期 4, 页码 376-383出版社
SPRINGER
DOI: 10.1080/13550280591002405
关键词
HSV-1; latency; microarray analysis; reactivation
资金
- NIAID NIH HHS [AI07324] Funding Source: Medline
- NINDS NIH HHS [NS 33768] Funding Source: Medline
In order to learn more about the cellular response to viral gene activity during latency and reactivation of herpes simplex virus type 1 (HSV-1), the authors have employed microarray analysis. On an array of about 1200 cellular genes, approximately 56 genes were found to be differentially regulated in infected trigeminal ganglia of mice, compared to uninfected mice, during latency and reactivation. Of these genes, 10 were examined more closely using quantitative real-time polymerase chain reaction (PCR) to confirm the microarray results. Genes involved in interferon and other signaling pathways appeared to predominate in response to a latent or reactivating HSV infection. Interestingly, some genes found to be differentially regulated in latently infected ganglia are neuronal-specific genes (pro-opiomelanocortinin; zinc finger proteins of the cerebellum 1 and 2). During reactivation, the involvement of several cell signaling molecules that may be important for the initiation of an HSV infection was observed, including various receptors and molecules involved in cell-cell spread.
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