期刊
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
卷 90, 期 8, 页码 4650-4658出版社
ENDOCRINE SOC
DOI: 10.1210/jc.2005-0628
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资金
- NICHD NIH HHS [R01-HD29364] Funding Source: Medline
- PHS HHS [K24-D01346] Funding Source: Medline
Context: The polycystic ovary syndrome ( PCOS) is the most common endocrine abnormality of reproductive-aged women today, affecting approximately 6.6% of unselected reproductive-aged women (similar to 4 million women in the United States) (1990 National Institutes of Health criteria), and potentially represents a significant financial burden to our health care. Objective: The objective of the study was to define, using current definitions and prevalence or incidencePatients or Other Participants: There were no patients or other participants. data, the minimal economic burden that PCOS in reproductive-aged women represents for the United States. Design: The study design was a literature review. Setting: The study was conducted at a tertiary care center. Patients or Other Participants: There were no patients or other participants. Intervention(s): We performed a systematic review of the published medical literature to identify studies evaluating epidemiology of reproductive-age PCOS and its clinical consequences and costs. We tied general societal cost data for the different health consequences to reproductive-age PCOS costs, using prevalence data. Results: We estimated the mean annual cost of the initial evaluation to be $93 million (2.1% of total costs), that of hormonally treating menstrual dysfunction/abnormal uterine bleeding to be $1.35 billion (31.0% of total), that of providing infertility care to be $533 million (12.2% of total), that of PCOS-associated diabetes to be $1.77 billion (40.5% of total), and that of treating hirsutism to be $622 million (14.2% of total). Conclusions: The total cost of evaluating and providing care to reproductive-aged PCOS women in the United States is $4.36 billion. Because the cost of the diagnostic evaluation accounted for a relatively minor part of the total costs (approximately 2%), more widespread and liberal screening for the disorder appears be a cost-effective strategy, leading to earlier diagnosis and intervention and possibly the amelioration and prevention of serious sequelae.
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