期刊
JOURNAL OF BIOLOGICAL RHYTHMS
卷 20, 期 4, 页码 375-386出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/0748730405278353
关键词
circadian rhythms; clinical disorders; clinical medicine; sleep disorders
资金
- NCRR NIH HHS [M01-RR02635, M01 RR002635] Funding Source: Medline
- NIA NIH HHS [P01 AG009975, P01-AG09775] Funding Source: Medline
- NICHD NIH HHS [R01 HD040291, K02 HD045459-03, K02 HD045459, K02 HD045459-02, K02 HD045459-05, R01 HD040291-03, R01 HD040291-02, K02-HD045459, R01-HD40291, K02 HD045459-04, R01 HD040291-01A1, K02 HD045459-01] Funding Source: Medline
Circadian rhythmicity can be important in the pathophysiology, diagnosis, and treatment of clinical disease. Due to the difficulties in conducting the necessary experimental work, it remains unknown whether similar to 24-h changes in pathophysiology or symptoms of many diseases are causally linked to endogenous circadian rhythms or to other diurnal factors that change across the day, such as changes in posture, activity, sleep or wake state, or metabolic changes associated with feeding or fasting. Until the physiology is accurately known, appropriate treatment cannot be. designed. This review includes an overview of clinical disorders that are caused or affected by circadian or diurnal rhythms. The clinical side effects of disruption of circadian rhythmicity, such as in shiftwork, including the public health implications of the disrupted alertness and performance, are also discussed.
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