期刊
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 77, 期 8, 页码 2727-2733出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.02454-10
关键词
-
资金
- BioEnergy Science Center (BESC) at Oak Ridge National Laboratory, a Department of Energy Bioenergy Research Center
- UCLA-DOE Institute for Genomics and Proteomics
Producing biofuels directly from cellulose, known as consolidated bioprocessing, is believed to reduce costs substantially compared to a process in which cellulose degradation and fermentation to fuel are accomplished in separate steps. Here we present a metabolic engineering example for the development of a Clostridium cellulolyticum strain for isobutanol synthesis directly from cellulose. This strategy exploits the host's natural cellulolytic activity and the amino acid biosynthesis pathway and diverts its 2-keto acid intermediates toward alcohol synthesis. Specifically, we have demonstrated the first production of isobutanol to approximately 660 mg/liter from crystalline cellulose by using this microorganism.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据