期刊
VIRUS RESEARCH
卷 111, 期 2, 页码 214-223出版社
ELSEVIER
DOI: 10.1016/j.virusres.2005.04.010
关键词
demyelinating disease; immunopathology; multiple sclerosis model; oligodendrocyte infection; Theiler's virus; Theiler's murine encephalomyelitis virus (TMEV)
类别
Theiler's murine encephalomyelitis virus (TMEV) infection of mice, in which persistent central nervous system (CNS) infection induces Th1 CD4(+) T cell responses to both virus and myelin proteins, provides a relevant experimental animal model for MS. During persistence, > 10(9) TMEV genome equivalents per spinal cord are detectable by real-time reverse transcription-polymerase chain reaction (RT-PCR). Because of the short half-life of TMEV (< 1 day), continual viral replication is needed to sustain these very high TMEV copy numbers. An essential role for macrophages in TMEV persistence has been documented and, although limited by host anti-viral immune responses, TMEV nonetheless spreads during persistence to infect other cells, particularly oligodendrocytes, in which the infection is productive and lytic. Virus factors influencing persistence of TMEV are expression of the out-of-frame L* protein and use of sialic acid co-receptors. (c) 2005 Elsevier B.V. All rights reserved.
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