A proof-of-concept study using [11C]flumazenil PET to demonstrate that pagoclone is a partial agonist

The GABA-ergic system is central to many anxiety disorders and has therefore received much attention. Benzodiazepines are highly effective anxiolytics, leading to their widespread use clinically. However, benzodiazepines often have unwanted side effects, such as sedation, amnesia and ataxia, in the short term. With longer use, tolerance and dependence associated with withdrawal have led to their use being limited or discouraged (NICE 2004).