期刊
EXPERT OPINION ON THERAPEUTIC TARGETS
卷 9, 期 4, 页码 699-713出版社
TAYLOR & FRANCIS LTD
DOI: 10.1517/14728222.9.4.699
关键词
astrocyte; c-Jun N-terininal kinase (JNK); dorsal horn; dorsal root ganglion (DPG); extracellular signal-regulated protein kinase (ERK) 1/2; microglia; mitogen-activated protein kinase (MAPK); nerve injury; neuropathic pain; p38
Peripheral nerve injury produces neuropathic pain as well as phosphorylationof mitogen activated protein kinase (MAPK) family in dorsal root ganglia (DRG) and dorsal horn. Following nerve injury, phosphorylation of extracellular signal-regulated protein kinase (ERK), an important member of this family, is sequentially increased in neurons, microglia and astrocytes of the dorsal horn and gracile nucleus, and in injured large DRG neurons. Nerve injury-induced phosphorylation of ERK occurs early and is long-lasting. In several animal models of neuropathic pain, MEK inhibitors, known to suppress the synthesis of ERK, have proven effective to alleviate pain at various time points. Thus, the regulation of ERK/MAPK can be considered as a promising therapeutic target for the treatment of neuropathic pain.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据