期刊
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 77, 期 5, 页码 1872-1877出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.02346-10
关键词
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资金
- Korean Systems Biology Program [MEST 2010-0002166]
- KOSEF [MEST 20100000322]
Through microarray analysis of an antibiotic-downregulator-deleted Streptomyces coelicolor Delta wblA Delta SCO1712 mutant, 28 wblA- and SCO1712-dependent genes were identified and characterized. Among 14 wblA- and SCO1712-independent genes, a carbon flux regulating 6-phosphofructokinase SCO5426 was additionally disrupted in the Delta wblA Delta SCO1712 mutant and further stimulated actinorhodin production in S. coelicolor, implying that both regulatory and precursor flux pathways could be synergistically optimized for antibiotic production.
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