期刊
NATURE NEUROSCIENCE
卷 8, 期 8, 页码 991-993出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1494
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资金
- NINDS NIH HHS [NS35102, R01 NS035102] Funding Source: Medline
Williams-Beuren syndrome (WBS), caused by a microdeletion of approximately 21 genes on chromosome 7q11.23, is characterized by unique hypersociability combined with increased non-social anxiety. Using functional neuroimaging, we found reduced amygdala activation in individuals with WBS for threatening faces but increased activation for threatening scenes, relative to matched normal controls. Activation and interactions of prefrontal regions linked to amygdala, especially orbitofrontal cortex, were abnormal, suggesting a genetically controlled neural circuitry for regulating human social behavior.
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