期刊
HEARING RESEARCH
卷 206, 期 1-2, 页码 146-158出版社
ELSEVIER
DOI: 10.1016/j.heares.2005.01.014
关键词
thalamocortical; intracortical; acetylcholine; receptive field; intracellular; synapse
资金
- NIDA NIH HHS [DA12929] Funding Source: Medline
- NIDCD NIH HHS [DC02967] Funding Source: Medline
Auditory cortex contributes to the processing and perception of spectro temporally complex stimuli. However, the mechanisms by which this is accomplished are not well understood. In this review, we examine evidence that single cortical neurons receive input covering much of the audible spectrum. We then propose an anatomical framework by which spectral information converges on single neurons in primary auditory cortex, via a combination of thalamocortical and intracortical horizontal pathways. By its nature, the framework confers sensitivity to specific, spectrotemporally complex stimuli. Finally, to address how spectral integration can be regulated, we show how one neuromodulator, acetylcholine, could act within the hypothesized framework to alter integration in single neurons. The results of these studies promote a cellular understanding of information processing in auditory cortex. (c) 2005 Elsevier B.V. All rights reserved.
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