期刊
JOURNAL OF PEDIATRICS
卷 147, 期 2, 页码 197-201出版社
MOSBY-ELSEVIER
DOI: 10.1016/j.jpeds.2005.05.015
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Objective To determine whether oral administration of the probiotic Lactobacillus GG under randomized, double-blinded, placebo-controlled conditions would improve symptoms of irritable bowel syndrome (IBS) in children. Study design Fifty children fulfilling the Rome II criteria for IBS were given Lactobacillus GG or placebo for 6 weeks. Response to therapy was recorded and collected on a weekly basis using the Gastrointestinal Symptom Rating Scale (GSRS). Results Lactobacillus GG was not superior to placebo in relieving abdominal pain (40.0% response rate in the placebo group vs 44.0% in the Lactobacillus GG group; P =.774). There was no difference in the other gastrointestinal symptoms, except for a lower incidence of perceived abdominal distention (P =.02 favoring Lactobacillus GG). Conclusions Lactobacillus GG was not superior to placebo in the treatment of abdominal pain in children with IBS but may help relieve such symptoms as perceived abdominal distention.
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