期刊
DRUG AND ALCOHOL DEPENDENCE
卷 79, 期 2, 页码 273-277出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.drugalcdep.2005.02.002
关键词
methamphetamine; inhibition; stop signal task; neuropsychology
资金
- NCRR NIH HHS [5M01RR000865-31] Funding Source: Medline
- NIDA NIH HHS [K01 DA0051-01A1, 3R01 DA015179-02S1] Funding Source: Medline
Chronic methamphetamine (MA) abuse is associated with cerebral deficits, involving frontal/basal-ganglia regions that are important for inhibitory control. We used the Stop-Signal Task to measure response inhibition in 11 MA abusers (5-7 days abstinent) and two groups of control subjects who did not use MA (14 tobacco smokers and 29 non-smokers). Stop-signal reaction time (SSRT), which indicates the latency to inhibit an initiated motor response, was significantly longer for MA abusers than for either control group (p's <.01). In contrast, the MA abusers did not differ from either group on Go trial reaction time (RT) or number of discrimination errors, which reflect motor speed and decision-processes. respectively. MA abuse in this study was therefore associated with a specific deficit in inhibiting a pre-potent response. Future research could examine whether SSRT is different for MA abusers who respond to treatment compared to those who do not. If such differences are established then response inhibition may serve as a marker for investigating MA abuse in basic science and clinical trials. (c) 2005 Elsevier Ireland Ltd. All rights reserved.
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