期刊
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 76, 期 19, 页码 6449-6454出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.02987-09
关键词
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资金
- Spanish Ministerio de Educacion y Ciencia/FEDER [AGL2005-02542]
- Consolider-Ingenio [CSD2007-0063]
- CICYT
Linalool production was evaluated in different Saccharomyces cerevisiae strains expressing the Clarkia breweri linalool synthase gene (LIS). The wine strain T-73 was shown to produce higher levels of linalool than conventional laboratory strains (i.e., almost three times the amount). The performance of this strain was further enhanced by manipulating the endogenous mevalonate (MVA) pathway: deregulated overexpression of the rate-limiting 3-hydroxy-3-methylglutaryl coenzyme A reductase (HMG-CoA reductase) doubled linalool production. In a haploid laboratory strain, engineering of this key step also improved linalool yield.
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