期刊
MOVEMENT DISORDERS
卷 20, 期 8, 页码 1031-1033出版社
WILEY
DOI: 10.1002/mds.20491
关键词
Alzheimer's disease; multiple system atrophy; Parkinson's disease; brain-derived neurotrophic factor; polymorphism
We studied two genetic polymorphisms (240C/T and 480G/A) of the brain-derived neurotrophic factor (BDNF) gene in Japanese patients with Alzheimer's disease (AD, n = 172), Parkinson's disease (PD, n = 327), and multiple system atrophy (MSA, n = 122), as well as controls (n = 275). The distribution of the 240 C/T polymorphism was significantly different between AD patients and controls, whereas there was no difference in the genotype of the two polymorphisms between MSA and controls or between PD and controls. Our data suggest that BDNF might play a role in AD. (c) 2005 Movement Disorder Society.
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