期刊
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
卷 116, 期 2, 页码 274-278出版社
MOSBY, INC
DOI: 10.1016/j.jaci.2005.04.039
关键词
asthma; allergy; genetics; gene-by-environment interactions
资金
- NHLBI NIH HHS [P50 HL056399, HL70831, R01 HL066533, R01 HL072414, HL56399, HL72414, HL66533] Funding Source: Medline
Although genetic linkage and association studies have identified more than 25 asthma or allergy susceptibility loci, replication of significant results remains a problem. Moreover, these approaches typically ignore the true complexity of these diseases, such as the role of gene-by-environment and gene-by-gene interactions. As a result, many important associations might have been missed. Recent studies demonstrate not only that such interactions exist but also that the relationship between genotype and phenotype is more complex than previously thought.
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