期刊
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 76, 期 24, 页码 8255-8258出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.00499-10
关键词
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资金
- NIH [AI063326]
- Howard Hughes Medical Institute
- USDA-Hatch Program
- Burroughs Welcome Fund
- Johnson Johnson
- DuPont
- Greater Milwaukee Foundation
- American Chemical Society Division of Medicinal Chemistry
We report the screening of 16,000 synthetic compounds for induction and inhibition of quorum sensing in a Pseudomonas putida N-acylated L-homoserine lactone (AHL) sensor strain engineered with the LasR transcriptional activator. LasR controls virulence gene expression in the opportunistic pathogen Pseudomonas aeruginosa and is of significant interest as a therapeutic target. Nine compounds that inhibit and 14 compounds that induce LasR activity were identified in our high-throughput screen.
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