4.7 Article

Preimplantation genetic diagnosis for aneuploidy screening in women older than 37 years

期刊

FERTILITY AND STERILITY
卷 84, 期 2, 页码 319-324

出版社

ELSEVIER SCIENCE INC
DOI: 10.1016/j.fertnstert.2005.02.019

关键词

advanced reproductive age; chromosomal aneuploidy; FISH; ICSI; IVF; PGD

向作者/读者索取更多资源

Objective: To provide background information about the average aneuploidy and implantation rates of older patients after IVF with preimplantation genetic diagnosis for aneuploidy screening (PGD-AS) when the patients are subdivided into age categories; and to compare pregnancy outcome data after PGD-AS in this group of patients with a similar control group. Design: Retrospective clinical study. Setting: Patients in an academic reproductive medicine unit. Patient(s): All patients 37 years or older who had PGD-AS between October 1999 and December 2003 and all pregnant patients 37 years or older who IVF/intracytoplasmic sperm injection without PGD-AS during the same period of time. Intervention(s): IVF with PGD-AS. Main Outcome Measure(s): Aneuploidy rate, miscarriage rate, live birth rate, implantation rate, multiple pregnancy rate, and prenatal testing. Result(s): Three hundred ninety-four PGD-AS cycles of patients between 37 and 46 years of age were analyzed. The aneuploidy rate gradually increased with age. The implantation rate remained similar over all age groups. There was a trend to a lower miscarriage and multiple pregnancy rate in the PGD-AS group and a higher delivery/live birth rate. There were five elective terminations of pregnancy after prenatal testing and three late miscarriages due to prenatal testing in the control group. Conclusion(s): Preimplantation genetic diagnosis for aneuploidy screening can give valuable information to older patients concerning the reason why their IVF cycles are unsuccessful and whether it is worthwhile to continue IVF treatment, and it can help patients to avoid the emotional trauma that can occur after prenatal testing during the second trimester of pregnancy.

作者

我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。

评论

主要评分

4.7
评分不足

次要评分

新颖性
-
重要性
-
科学严谨性
-
评价这篇论文

推荐

暂无数据
暂无数据