期刊
NATURE NEUROSCIENCE
卷 8, 期 8, 页码 1022-1027出版社
NATURE PUBLISHING GROUP
DOI: 10.1038/nn1508
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资金
- NCI NIH HHS [P01 CA023767, P01 CA23767] Funding Source: Medline
- NEI NIH HHS [EY014689, R01 EY014689] Funding Source: Medline
- NIDCD NIH HHS [R01 DC004209, R01 DC04209] Funding Source: Medline
- NIGMS NIH HHS [T32 GM008646, GM08646] Funding Source: Medline
In mammals, retinal ganglion cell (RGC) projections initially intermingle and then segregate into a stereotyped pattern of eye-specific layers in the dorsal lateral geniculate nucleus (dLGN). Here we found that in mice deficient for ephrin-A2, ephrin-A3 and ephrin-A5, eye-specific inputs segregated but the shape and location of eye-specific layers were profoundly disrupted. In contrast, mice that lacked correlated retinal activity did not segregate eye-specific inputs. Inhibition of correlated neural activity in ephrin mutants led to overlapping retinal projections that were located in inappropriate regions of the dLGN. Thus, ephrin-As and neural activity act together to control patterning of eye-specific retinogeniculate layers.
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