期刊
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY
卷 289, 期 2, 页码 G173-G176出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/ajpgi.00079.2005
关键词
antimicrobial peptide; innate immunity; Crohn's disease
资金
- NIAID NIH HHS [AI 50843, AI 32738] Funding Source: Medline
Events at the Host-Microbial Interface of the Gastrointestinal Tract. V. Paneth cell alpha-defensins in intestinal host defense. Am J Physiol Gastrointest Liver Physiol 289: G173-G176, 2005; doi:10.1152/ajpgi.00079.2005.-Host defense of the small intestine is mediated, in part, by antimicrobial peptides, including alpha-defensins. In the small intestine, Paneth cells, specialized secretory epithelial cells located at the base of the crypt invaginations lining the intestinal wall, produce alpha-defensins. The alpha-defensins are cysteine-rich cationic peptides with antibiotic activity against a wide range of bacteria and other microbes. Studies of transgenic and knockout mice have supported a pivotal role of Paneth cell alpha-defensins in protection from bacterial pathogens. New data suggest that deficient expression of Paneth cell alpha-defensins may contribute to the pathophysiology of Crohn's disease, a chronic inflammatory bowel disease.
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