期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 16, 期 4-5, 页码 585-595出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2005.07.006
关键词
gene expression; myogenesis; development; chromatin
The basic helix-loop-helix myogenic regulatory factors MyoD, Myf5, myogenin and MRF4 have critical roles in skeletal muscle development. Together with the Mef2 proteins and E proteins, these transcription factors are responsible for coordinating muscle-specific gene expression in the developing embryo. This review highlights recent studies regarding the molecular mechanisms by which the muscle-specific myogenic bHLH proteins interact with other regulatory factors to coordinate gene expression in a controlled and ordered manner. (c) 2005 Elsevier Ltd. All rights reserved.
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