4.6 Article

Pyrosequencing of the Genital Microbiotas of HIV-Seropositive and -Seronegative Women Reveals Lactobacillus iners as the Predominant Lactobacillus Species

期刊

APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 77, 期 1, 页码 378-381

出版社

AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.00973-10

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资金

  1. NIH [P01 AI082971]
  2. Chicago Women's Interagency HIV Study (WIHS)
  3. National Institute of Allergy and Infectious Diseases [UO1 34993]
  4. National Cancer Institute
  5. National Institute on Drug Abuse [UO1 AI35004, UO1 AI31834, UO1 AI34994, UO1 AI34989, UO1 AI34993, UO1 AI42590]
  6. National Institute of Child Health and Human Development [UO1 HD 23632]
  7. National Center for Research Resources [MO1-RR-00071, MO1-RR-00079, MO1-RR-00083]
  8. [P30 AI082151]
  9. NATIONAL CENTER FOR RESEARCH RESOURCES [M01RR000083, M01RR000071, M01RR000079] Funding Source: NIH RePORTER
  10. NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES [U01AI034994, U01AI034989, U01AI031834, U01AI035004, U01AI042590, P30AI082151, U01AI034993, P01AI082971] Funding Source: NIH RePORTER

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The species of vaginal lactobacilli in HIV-seropositive and -seronegative women were determined by 16S gene pyrosequencing. Lactobacillus iners sequences were the predominant lactobacillus sequences in 66% of HIV+ women and 90% of HIV- women. This has implications for resistance of HIV+ and HIV- women to genital colonization by pathogenic organisms.

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