期刊
CHEMBIOCHEM
卷 6, 期 8, 页码 1368-1374出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cbic.200500035
关键词
cosmic-dust analogues; nucleic acids; nucleobases; oligonucleotides; pyrimidines
We show the unprecedented one-pot synthesis of a large suite of pyrimidines (including cytosine and uracil) and purines from formomide in the presence of cosmic-dust analogues (CDAs) of olivines. Since the major problem in the origin of informational macromolecules is the instability of their precursors, we also investigate the stabilizing effect of CDAs on the intrinsic instability of oligonucleotides in formamide.
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