期刊
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 75, 期 22, 页码 7291-7293出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.01402-09
关键词
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资金
- 21C Frontier Microbial Genomics and Application Center Program
- Ministry of Science and Technology, Republic of Korea [11-2008-14-007-00]
- National Research Foundation of Korea [11-2008-14-007-00] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Putative hopanoid genes from Streptomyces peucetius were introduced into Escherichia coli to improve the production of squalene, an industrially important compound. High expression of hopA and hopB (encoding squalene/phytoene synthases) together with hopD (encoding farnesyl diphosphate synthase) yielded 4.1 mg/liter of squalene. This level was elevated to 11.8 mg/liter when there was also increased expression of dxs and idi, E. coli genes encoding 1-deoxy-D-xylulose 5-phosphate synthase and isopentenyl diphosphate isomerase.
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