期刊
TETRAHEDRON
卷 61, 期 31, 页码 7438-7446出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2005.05.071
关键词
Suzuki coupling; imidazolium; carbene; palladium
A novel bis-phenanthryl N-heterocyclic carbene (NHC) based palladium acetate catalyst was effective for the coupling of various aryl and vinyl chlorides with organoboron compounds. N,N-Bis-(2,9-dicyclohexyl-10-phenanthryl)-4,5-dibydroimidazolium chloride 8 (H2ICP center dot HCl) with Pd(OAc)(2) and KF center dot 18-c-6 in THF at room temperature gave Suzuki-Miyaura coupling of aryl and vinyl chorides, including unactivated and di-ortho substituted substrates in high yields. Hindered tri- and tetra-ortho substituted products were also efficiently produced. Benzyl chloride was also found to be a useful coupling partner and trimethylboroxine was used to give methylated products. The effect of ligand, base, temperature, solvent, and reaction time are reported along with various substrates including halides and triflates. (c) 2005 Elsevier Ltd. All rights reserved.
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