期刊
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 75, 期 9, 页码 2958-2963出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.02325-08
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资金
- Marlene and Stewart Greenebaum Cancer Center's American Cancer Society Institutional Research [01-4-30170]
- National Institutes of Health [GM084473]
- University of Maryland, College Park
Tomaymycin produced by Streptomyces achromogenes is a naturally produced pyrrolobenzodiazepine (PBD). The biosynthetic gene cluster for tomaymycin was identified and sequenced. The gene cluster analysis reveals a novel biosynthetic pathway for the anthranilate moiety of PBDs. Gene replacement and chemical complementation studies were used to confirm the proposed biosynthetic pathway.
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