期刊
BIOCHEMICAL SOCIETY TRANSACTIONS
卷 33, 期 -, 页码 548-550出版社
PORTLAND PRESS LTD
DOI: 10.1042/BST0330548
关键词
Alzheimer's disease; H2O2; neuradegeneration; Parkinson's disease; prion; protein aggregation
资金
- Wellcome Trust Funding Source: Medline
By means of an ESR spin-trapping method, we have shown that A beta (amyloid beta), alpha-synuclein and various toxic forms of the prion protein all appear to generate H2O2 in vitro. A fundamental molecular mechanism underlying the pathogenesis of cell death in several different neurodegenerative diseases could be the direct production of H2O2 during the early stages of protein aggregation.
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