期刊
APPLIED AND ENVIRONMENTAL MICROBIOLOGY
卷 75, 期 6, 页码 1778-1781出版社
AMER SOC MICROBIOLOGY
DOI: 10.1128/AEM.00859-08
关键词
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资金
- National Science Foundation of China
- Ministry of Science and Technology (973 and 863 programs)
- Science and Technology Committee of Shanghai Municipality [07DZ19503-4]
Tailoring steps are often important for the activity of mature antibiotics. Here, we report that novel decarboxylated FR-008/candicidin derivatives were obtained from the P450 monooxygenase gene fscP mutant of Streptomyces sp. strain FR-008. The toxicity of decarboxylated FR-008/candicidin derivatives has been shown to be greatly reduced compared to that of wild-type FR-008/candicidin.
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