期刊
JOURNAL OF CLINICAL GASTROENTEROLOGY
卷 39, 期 7, 页码 600-602出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/01.mcg.0000170769.67320.47
关键词
constipation; polyethylene glycol; laxative
Purpose: PEG 3350 (MiraLax, Braintree Laboratories Inc., Braintree, MA) 17 g daily has been shown to be safe and effective in a 14-day trial for constipation. This present investigation was designed to extend the treatment and safety experience with PEG 3350 and to evaluate any lasting effectiveness during a 30-day posttreatment observation period. Methods: Study subjects met Rome II criteria for constipation and reported < 3 bowel movements a week. They were treated with PEG 3350 17 g daily for 14 days. Treatment efficacy was defined by resolution of constipation symptoms as determined by the Rome II and stool frequency definitions during the treatment period. Results: Fifty healthy constipated subjects formed the study group. There were 42 females and 8 males. Mean age was 52 +/- 15.5 years (+/- SD). Symptom duration was 22.6 +/- 16.7 months (+/- SD). At baseline, all had < 3 bowel movements a week and met Rome II criteria. Two were lost to follow-up. Two took enemas or laxatives and 2 discontinued active treatment because of gas and were considered treatment failures. At the end of 14 days, 40 of 48 (83.3%) had > 3 stools in the last week and no longer met Rome criteria. Thirty-two of 45 (71.1%) reported satisfaction with the first bowel movement after initiating treatment. Thirty days after active treatment, 29 of 47 (61.7%) responded that they needed laxative treatment. Conclusion: PEG 3350 relieved constipation in most treated study subjects. During a 30-day post-treatment observation period, 29 of 47 (61.7%) had additional constipation treatment interventions.
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