期刊
TECHNOLOGY IN CANCER RESEARCH & TREATMENT
卷 4, 期 4, 页码 363-374出版社
SAGE PUBLICATIONS INC
DOI: 10.1177/153303460500400405
关键词
nanoparticles; bioconjugates; tumor cells; vasculature; anticancer agents
类别
Chemotherapy has been the main modality of treatment for cancer patients; however, its success rate remains low, primarily due to limited accessibility of drugs to the tumor tissue, their intolerable toxicity, development of multi-drug resistance, and the dynamic heterogeneous biology of the growing tumors. Better understanding of tumor biology in recent years and new targeted drug delivery approaches that are being explored using different nanosystems and bioconjugates provide optimism in developing successful cancer therapy. This article reviews the possibilities and challenges for targeted drug delivery in cancer therapy.
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